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Using Detachment‐Promoting Agents for the Prevention of Chronic Peritoneal Dialysis‐Associated Infections
Author(s) -
Branger Bernard,
Marion Karine,
Bergeron Emmanuelle,
Perret Cécile,
Zabadani Bachir,
Reboul Pascal,
Freney Jean
Publication year - 2008
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2008.00684.x
Subject(s) - peritoneal dialysis , biofilm , medicine , dialysis , chronic pyelonephritis , urology , biology , bacteria , genetics
Biofilms are known to be responsible for chronic peritoneal dialysis (PD)‐related infections. Such infections are still frequent among patients in PD. The aim of this study was to develop a new approach in the prevention of chronic PD‐related infection by regular injection of specific formulations containing detachment‐promoting agents. A biofilm reactor system reproducing PD‐like operating conditions was developed. A first set of experiments allowed the assessment of the anti‐biofilm efficacy of various formulations. Then, experiments were performed for a longer duration and selected formulations were tested and compared with taurolidine. Biofilm removal was quantified by calculating the percentage of coverage reduction compared with an untreated control. A regular weekly treatment led to a 97% reduction of the surface coverage although a daily treatment with taurolidine still left 48% of the biomass on the surface. Such treatment is recommended to reduce the frequencies of chronic PD‐related infections.