Premium
The Relationship Between Leptin Level and Oxidative Status Parameters in Hemodialysis Patients
Author(s) -
Horoz Mehmet,
Aslan Mehmet,
Koylu Ahmet O.,
Bolukbas Cengiz,
Bolukbas Filiz F.,
Selek Sahbettin,
Erel Ozcan
Publication year - 2009
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2008.00678.x
Subject(s) - leptin , oxidative stress , medicine , hemodialysis , endocrinology , antioxidant capacity , body mass index , obesity
Both serum leptin level and oxidative stress are increased in hemodialysis (HD) patients. In the present study, we aimed to investigate whether there is association between oxidative status and leptin level in HD patients. Thirty‐five HD patients and 25 healthy controls were enrolled in the present study. Serum leptin level, total peroxide (TP) level, total antioxidant capacity (TAC), and oxidative stress index (OSI) were determined. Serum leptin level, TP level, and OSI were significantly higher in HD patients than controls (all P < 0.001) while TAC was lower ( P < 0.001). In HD patients, serum leptin level was significantly correlated with TP level and OSI ( r = 0.372, P < 0.001 and r = 0.409, P < 0.001, respectively). The correlation of serum leptin level with TP level and OSI remained statistically significant after adjusting for age, gender, and body‐fat percentage ( r = 0.446, P < 0.001 and r = 0.463, P < 0.001, respectively). Hyperleptinemia seems to be associated with increased oxidative stress in HD patients, and this association may provide better understanding about the disorders related to either elevated serum leptin levels and/or increased oxidative stress in HD patients.