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Photocrosslinkable Chitosan Hydrogel Can Prevent Bone Formation in Both Rat Skull and Fibula Bone Defects
Author(s) -
Tsuda Yoshifumi,
Ishihara Masayuki,
Amako Masatoshi,
Arino Hiroshi,
Hattori Hidemi,
Kanatani Yasuhiro,
Yura Hirofumi,
Nemoto Koichi
Publication year - 2009
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2008.00676.x
Subject(s) - chitosan , skull , fibula , chemistry , biomedical engineering , materials science , anatomy , tibia , medicine , biochemistry
UV light irradiation to a photocrosslinkable chitosan (Az‐CH‐LA) resulted in an insoluble and flexible hydrogel within 30 s. The purpose of this study was to evaluate the ability of the photocrosslinkable chitosan to inhibit bone formation in the bone defects. A 5‐mm‐diameter defect was made in the rat calvarium, and then photocrosslinkable chitosan was implanted and irradiated with UV for 30 s. Furthermore, a 2‐mm defect was made in the fibula of a rat hind leg, and then photocrosslinkable chitosan was implanted and irradiated with UV. Bone formations in the rat skull and fibula defects with photocrosslinkable chitosan hydrogel were significantly prevented for 8 weeks. Thus, the chitosan hydrogel has an inhibitory effect on bone formation.