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Comparison of a Pulsatile Blood Pump and a Peristaltic Roller Pump During Hemoperfusion Treatment in a Canine Model of Paraquat Poisoning
Author(s) -
Lee Jung Chan,
Park Chan Young,
Choi Seong Wook,
Kim Jeong Chul,
Lim Ki Moo,
Kim Kyuseok,
Jung Sung Koo,
Kwak Young Ho,
Shin Sang Do,
Jo Ik Joon,
Suh Gil Joon,
Min Byoung Goo
Publication year - 2008
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2008.00582.x
Subject(s) - hemoperfusion , peristaltic pump , paraquat , anesthesia , pulsatile flow , infusion pump , blood flow , whole blood , chemistry , medicine , surgery , hemodialysis , biochemistry , physics , meteorology
This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat‐poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T‐PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T‐PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T‐PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4‐h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T‐PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device.