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Antithrombogenic Polynitrosated Polyester/Poly(methyl methacrylate) Blend for the Coating of Blood‐Contacting Surfaces
Author(s) -
Seabra Amedea B.,
Da Silva Regiane,
De Souza Gabriela F.P.,
De Oliveira Marcelo G.
Publication year - 2008
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2008.00540.x
Subject(s) - polyester , materials science , methyl methacrylate , polymer chemistry , coating , methacrylate , ethylene glycol , scanning electron microscope , poly(methyl methacrylate) , polymer , nuclear chemistry , chemical engineering , copolymer , composite material , chemistry , organic chemistry , engineering
A nitric oxide (NO) donor polyester containing multiple S‐nitrosothiol (S‐NO) groups covalently attached to the polymer backbone was synthesized through the esterification of poly(ethylene glycol) with mercaptosuccinic acid, followed by the nitrosation of the –SH moieties. The polynitrosated polyester (PNPE) obtained was blended with poly(methyl methacrylate) (PMMA), yielding solid films capable of releasing NO. Scanning electron microscopy analysis showed that acrylic plates and stainless steel intracoronary stents can be coated with continuous and adherent PNPE/PMMA films. After an initial NO burst, these films release NO spontaneously in dry condition or immersed in aqueous solution at constant rates of 1.8 and 180 nmol/g/h, respectively, for more than 24 h at physiological temperature. PNPE/PMMA coated surfaces were shown to inhibit platelet adhesion when in contact with whole blood. These results show that PNPE/PMMA blend can be used for the coating of blood‐contacting surfaces, with potential to inhibit thrombosis and restenosis after stenting.