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Innovative, Replaceable Heart Valve: Concept, In Vitro Study, and Acute In Vivo Study
Author(s) -
Fukamachi Kiyotaka,
Ootaki Yoshio,
Ootaki Chiyo,
Akiyama Masatoshi,
Kamohara Keiji,
Cingoz Faruk,
Chen JiFeng,
Horvath David J.,
Massiello Alex L.,
Dessoffy Raymond
Publication year - 2008
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2007.00527.x
Subject(s) - magnet , coupling (piping) , ring (chemistry) , mitral valve , base (topology) , mitral valve replacement , mechanical heart , biomedical engineering , materials science , mechanical engineering , chemistry , engineering , cardiology , medicine , mathematics , mathematical analysis , organic chemistry
The purpose of this study was to evaluate the feasibility of our innovative, replaceable heart valves that can be easily detached from the sewing ring at the time of repeat replacement. The prototype devices consist of the base magnet ring assembly and the valve magnet ring assembly that utilize magnetic coupling force for the locking mechanism. Magnetic coupling strength was evaluated in vitro. Prototype bioprosthetic valves were implanted acutely in three sheep to confirm the feasibility of the replaceable mitral valve. The static separation force of prototype size #25 was 12.5 lb, meeting the design goal. In situ attachment and detachment of the valve magnet ring assembly from the base magnet ring assembly were very easily accomplished in all animals. The magnetic coupling did not decouple even under extremely high left ventricular pressures. We have demonstrated the feasibility of this innovative concept of a replaceable mitral valve.