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Study on Decellularized Porcine Aortic Valve/Poly (3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) Hybrid Heart Valve in Sheep Model
Author(s) -
Wu Song,
Liu YingLong,
Cui Bin,
Qu XiangHua,
Chen GuoQiang
Publication year - 2007
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2007.00442.x
Subject(s) - decellularization , heart valve , calcification , biomedical engineering , cardiopulmonary bypass , aortic valve , in vivo , materials science , tissue engineering , medicine , biology , microbiology and biotechnology
To overcome shortcomings of current heart valve prostheses, novel hybrid valves were fabricated from decellularized porcine aortic valves coated with poly (3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate [PHBHHx]). In the mechanical test in vitro, the biomechanical performance of hybrid valve was investigated. In an in vivo study, hybrid valve conduits were implanted in pulmonary position in sheep without cardiopulmonary bypass. Uncoated grafts were used as control. The valves were explanted and examined histologically and biochemically 16 weeks after surgery. The hybrid valve conduits maintained original shapes, were covered by a confluent layer of cells, and had less calcification than uncoated control. The mechanical test in vitro revealed that PHBHHx coating improved tensile strength. The results in vivo indicated that PHBHHx coating reduced calcification and promoted the repopulation of hybrid valve with the recipient's cells resembling native valve tissue. The hybrid valve may provide superior valve replacement with current techniques.