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Convection‐enhanced High‐Flux Hemodialysis
Author(s) -
Lee Kyungsoo,
Jeong Jae Hoon,
Mun Cho Hae,
Lee Sa Ram,
Yoo Kyu Jae,
Park Yong Woo,
Won Yong Soon,
Min Byoung Goo
Publication year - 2007
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2007.00436.x
Subject(s) - filtration (mathematics) , chemistry , hemodialysis , chromatography , filtration fraction , pressure drop , renal function , biomedical engineering , surgery , renal blood flow , mechanics , medicine , mathematics , biochemistry , statistics , physics
Internal filtration contributes to convective clearance in high‐flux hemodialysis but its contribution is limited by low pressure gradients. Therefore, a modification using a conventional dialyzer was conceived to enhance internal filtration and backfiltration (BF) rates. The modified dialyzer includes two longitudinal independent regions for blood flow, which were created by redesigning dialyzer caps. Blood pressures remained higher than dialysate pressures in one region and lower in the other region, allowing continuous internal filtration and BF in these respective regions. Modified and conventional dialyzers were compared in terms of pressure gradients and solute clearances. Thus, our experiments involved two groups: the modified dialyzer group and the conventional dialyzer group. A renal failure model was established using a dog weighing 25–30 kg by renal artery and vein ligation. With the exception of the dialyzers, experimental conditions were identical in the two groups. The pressure gradients between blood and dialysate were much higher for the modified dialyzer than for the conventional dialyzer. No significant differences were observed with respect to small solute clearances between the two groups, but mid‐range solute clearances were significantly higher in the modified group. More optimization is required before the devised unit can be used clinically. However, the devised unit offers a straightforward means of regulating internal filtration and BF rates.