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Enhancement of Peripheral Nerve Regeneration Using Bioabsorbable Polymer Tubes Packed With Fibrin Gel
Author(s) -
Nakayama Kazuya,
Takakuda Kazuo,
Koyama Yoshihisa,
Itoh Soichiro,
Wang Wei,
Mukai Tomokazu,
Shirahama Noriaki
Publication year - 2007
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2007.00418.x
Subject(s) - fibrin , tube (container) , regeneration (biology) , materials science , biomedical engineering , bellows , peripheral nerve , anatomy , composite material , medicine , metallurgy , immunology , biology , microbiology and biotechnology
  Nerve conduit tubes were developed using bioabsorbable polymer membranes, and the effects of tube shape—straight or bellows‐shaped tubes—and the fibrin gel filling were investigated. The mechanical properties of the tubes were examined by in vitro tests, and their effectiveness for peripheral nerve regeneration was determined by grafting into experimentally transected sciatic nerves of rats. The bellows tube showed mechanically superior properties, and when used with the fibrin gel, it induced superior tissue formation of myelinated nerve fibers as compared to other tube types. The total area of myelinated axons regenerated in the fibrin‐filled bellows tube was comparable to that of an isograft control, whereas those of the other tubes demonstrated inferior regeneration. This result suggests that the mechanically superior bellows tube filled with fibrin gel is an effective graft alternative for peripheral nerve regeneration.

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