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Intermittent Stops of Shear Reduce the Mechanical Damage of Red Blood Cells
Author(s) -
Mizunuma Hiroshi,
Sakai Shirou
Publication year - 2007
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2007.00408.x
Subject(s) - hemolysis , shear (geology) , materials science , red blood cell , shear stress , shear flow , mechanics , composite material , medicine , physics
Continuous and intermittent high shear were loaded to red blood cells in a cone and a plate rheoscope. The mechanical damage to red cells was compared for continuous and intermittent shear. The intermittent shear was achieved by alternately starting and stopping shear repeatedly. In the case of intermittent shear load, red cell damage was suppressed remarkably. To explain this effect, we introduced a phenomenological hemolysis model, which agreed reasonably with the hemolysis tests for intermittent shear flow.