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An In Vitro and In Vivo Study of the Detection and Reversal of Venous Collapse During Extracorporeal Life Support
Author(s) -
Simons Antoine P.,
Reesink Koen D.,
Molegraaf Georgette V.,
Van Der Nagel Theo,
De Jong Monique M.,
Severdija Ervin E.,
De Jong Dick S.,
Van Der Veen Frederik H.,
Maessen Jos G.
Publication year - 2007
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2007.00356.x
Subject(s) - extracorporeal , centrifugal pump , extracorporeal circulation , in vivo , biomedical engineering , peristaltic pump , medicine , vein , life support , materials science , anesthesia , surgery , engineering , intensive care medicine , mechanical engineering , microbiology and biotechnology , impeller , biology
The objective of this study was to investigate venous collapse (VC) related to venous drainage during the use of an extracorporeal life support circuit. A mock circulation was built containing a centrifugal pump and a collapsible vena cava model to simulate VC under controlled conditions. Animal experiments were performed for in vivo verification. Changing pump speed had a different impact on flow during a collapsed and a distended caval vein in both models. Flow measurement in combination with pump speed interventions allows for the detection and quantitative assessment of the degree of VC. Additionally, it was verified that a quick reversal of a VC situation could be achieved by a two‐step pump speed intervention, which also proved to be more effective than a straightforward decrease in pump speed.