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Late Results of Gelatin–Resorcin–Formalin Glue‐aided Repair in Acute Type A Aortic Dissection
Author(s) -
Shiono Motomi,
Hata Mitsumasa,
Sezai Akira,
Niino Tetsuya,
Yagi Shinya,
Negishi Nanao
Publication year - 2006
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2006.00328.x
Subject(s) - medicine , glue , hemostasis , surgery , aortic dissection , lumen (anatomy) , mortality rate , dissection (medical) , necrosis , aorta , materials science , composite material
Gelatin–resorcin–formalin (GRF) glue has been used to obliterate the false lumen of dissected aortas, resulting in reduced mortality. However, because of the cytotoxicity of formalin, the application of GRF remains controversial. In this study, a total of 138 consecutive patients with acute type A dissection since 1995, who underwent emergency graft replacement, were reviewed. The mean age was 65.5 years. The hospital mortality rate was 6.5%. In‐hospital re‐exploration rate and patency rate of the false lumen were 6.5% and 24.7%, respectively. The actuarial survival rates were 81.5% after 5 years and 54.8% after 10 years. Reoperation‐free rates were 87.9% after 5 years and 72.3% after 10 years. Tissue necrosis or aneurismal degeneration was not demonstrated at reoperation. In conclusion, GRF glue demonstrats excellent tissue adhesion and hemostasis capability, and contributes to improve surgical results.