Premium
Evaluation of Liver Support Systems for Preclinical Testing by Animal Trials
Author(s) -
Seleverstov Oleksandr,
Bader Augustinus
Publication year - 2006
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2006.00305.x
Subject(s) - animal testing , preclinical testing , medicine , intensive care medicine , medical physics , biology , ecology
Abstract: In the present review, various animal models of acute liver failure are reviewed with respect to their suitability for evaluating liver support systems (LSS) according to envisaged modes of therapy. In order to increase the value of the preclinical testing of LSS, it would be advantageous to include more than one animal model in the evaluation program. It is possible to identify appropriate sets of models, which make a suitable test system for particular clinical applications. A standardization of evaluation methods between testing groups would also be beneficial to the field of liver support.