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Comparison Between Intermittent and Continuous Measurement of Cardiac Output After Acute Normovolemic Hemodilution in Pigs
Author(s) -
Otsuki Denise A.,
Cardieri Fernando A.,
Schmidt André P.,
Brudniewski Marcio,
Fantoni Denise T.,
Auler José O.C.
Publication year - 2006
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2006.00242.x
Subject(s) - hydroxyethyl starch , medicine , cardiac output , anesthesia , pulmonary artery catheter , hemodynamics , critically ill , catheter , continuous monitoring , surgery , operations management , economics
Continuous cardiac output (CO) and mixed venous oxygen saturation (SvO 2 ) determined through the pulmonary artery catheter may be helpful in monitoring hemodynamic conditions in critically ill patients. This study aimed to evaluate CO and SvO 2 in a model of acute normovolemic hemodilution (ANH), analyzing the accuracy of the continuous versus intermittent method for CO and SvO 2 measurement in pigs. Twenty‐three pigs were enrolled to three groups: control, ANH with 6% hydroxyethyl starch (HES), or ANH with lactated Ringer’s (LR) solution. After hemodilution, we showed that SvO 2 was reduced in both groups, mainly in LR animals ( P < 0.05). Regarding the evaluation of CO, we showed an increase in both groups submitted to ANH ( P < 0.05). Through Bland–Altman analysis, we showed that the continuous CO catheter presented lower values than the intermittent method after hemodilution, mainly with HES ( P < 0.001), and there was no difference in the measurement of SvO 2 . The ANH promoted a decrease in SvO 2 and an increase in CO values, mainly in animals submitted to hemodilution with HES. The use of continuous and intermittent (laboratory) measurement of SvO 2 showed clinical applicability and good agreement, an effect not reproduced by the CO measurement. New studies are needed to further investigate the agreement between the continuous and intermittent methods for the measurement of CO in adverse hemodynamic conditions such as ANH.