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Hydrodynamic Evaluation of Kangaroo Aortic Valve Matrices for Tissue Valve Engineering
Author(s) -
Narine Kishan K.,
Kramm Katarzyna,
Dumont Kris,
Jalali Homayoun,
Sparks Lisa,
Segers Patrick,
Verdonck Pascal,
Van Nooten Guido J.
Publication year - 2006
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2006.00238.x
Subject(s) - pulsatile flow , aortic valve , heart valve , medicine , cardiology , biomedical engineering
We evaluated the hydrodynamic performance of kangaroo aortic valve matrices (KMs) (19, 21, and 23 mm), as potential scaffolds in tissue valve engineering using a pulsatile left heart model at low and high cardiac outputs (COs) and heart rates (HRs) of 60 and 90 beats/min. Data were measured in two samples of each type, pooled in two CO levels (2.1 ± 0.7 and 4.2 ± 0.6 L/min; mean ± standard errors on the mean), and analyzed using analysis of variance with CO level, HR, and valve type as fixed factors and compared to similar porcine matrices (PMs). Transvalvular pressure gradient (ΔP) was a function of HR ( P < 0.001) and CO ( P < 0.001) but not of valve type ( P = 0.39). ΔP was consistently lower in KMs but not significantly different from PMs. The effective orifice area and performance index of kangaroo matrices was statistically larger for all sizes at both COs and HRs.