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Tissue Engineering Approach to the Treatment of Bone Tumors: Three Cases of Cultured Bone Grafts Derived From Patients’ Mesenchymal Stem Cells
Author(s) -
Morishita Toru,
Honoki Kanya,
Ohgushi Hajime,
Kotobuki Noriko,
Matsushima Asako,
Takakura Yoshinori
Publication year - 2006
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2006.00190.x
Subject(s) - mesenchymal stem cell , osteoblast , bone marrow , bone healing , medicine , tissue engineering , curettage , matrix (chemical analysis) , demineralized bone matrix , bone tissue , pathology , biomedical engineering , surgery , chemistry , materials science , dbm , in vitro , amplifier , biochemistry , optoelectronics , cmos , chromatography
A novel approach to the treatment of bone tumors using tissue‐engineered implants is reported in this study. The number of mesenchymal stem cells (MSCs) obtained from each patient's bone marrow cells was first increased, and the MSCs were forced to differentiate into osteoblasts followed by bone matrix formation on hydroxyapatite (HA) ceramics. The strong osteogenic ability of the implants, as evidenced by high osteoblastic activity, was confirmed. Consequently, the HA surface was covered with the patient's derived cultured osteoblast/bone matrix. The tissue‐engineered HA was used to fill the patient's bone cavity after tumor curettage. Immediate healing potential was found by serial plain radiographs and computed tomograhy images, and no adverse reactions were noted in these patients. The results indicate that tissue‐engineered osteogenic ceramics might be an alternative to autologous bone grafts.