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TNF Alpha−308 Genotype and Renin–Angiotensin System in Hemodialysis Patients: An Effect on Inflammatory Cytokine Levels?
Author(s) -
Genctoy Gultekin,
Altun Bulent,
Alper Kiykim Ahmet,
Arici Mustafa,
Erdem Yunus,
Çağlar Meltem,
Yasavul Ünal,
Turgan Çetin,
Çağlar Şali
Publication year - 2005
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2005.29029.x
Subject(s) - proinflammatory cytokine , tumor necrosis factor alpha , medicine , endocrinology , renin–angiotensin system , cytokine , hemodialysis , inflammation , angiotensin converting enzyme , immunology , blood pressure
Background: Renin–angiotensin system (RAS) was suggested to modulate inflammatory cytokine production. Angiotensin II was consistently shown to increase production of tumor necrosis factor alpha (TNF‐α). However, inflammatory cytokines and RAS were modulated by genetic polymorphisms such as TNF‐α−308 G > A and angiotensin‐converting enzyme (ACE) I/D gene polymorphisms. The aim of this study was to investigate the effects of ACE and TNF‐α genotypes on inflammatory cytokines in hemodialysis (HD) patients. Methods: ACE I/D and TNF‐α−308 G > A genotypes, pre‐ and postdialysis plasma renin activity (PRA), serum ACE, interleukin‐1 beta (IL‐1β), and TNF‐α levels were determined in 22 HD patients. Results: Predialysis serum ACE activity is correlated with TNF‐α ( r = 0.63; P = 0.01), and PRA was correlated with IL‐1β levels ( r = 0.49; P = 0.02). Pre/postdialysis IL‐1β and TNF‐α were similar in DD and II/ID ACE genotypes. Predialysis TNF‐α and IL‐1β (32.4 ± 5; 35.1 ± 4.2 vs. 28.1 ± 3.7; 26.5 ± 6.2 pg/mL; P < 0.05) and postdialysis TNF‐α levels (30.4 ± 1.4 vs. 28.4 ± 0.82 pg/mL; P < 0.05) were significantly higher in TNF1/2 than TNF1/1 patients. Conclusion: ACE and TNF‐α−308 G > A (1/2) gene polymorphisms may contribute to modulation of proinflammatory cytokine production and hence chronic inflammation in HD patients.