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Diabetes‐induced Alterations in Latissimus Dorsi Muscle Properties Impair Effectiveness of Dynamic Cardiomyoplasty in Rats
Author(s) -
De Angelis Kátia,
Senna Sueli,
Irigoyen Maria Cláudia,
Cestari Idágene A.
Publication year - 2004
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2004.47349.x
Subject(s) - isometric exercise , cardiomyoplasty , medicine , diabetes mellitus , endocrinology , cardiology , latissimus dorsi muscle , streptozotocin , blood pressure , anatomy , heart failure
Short‐term diabetes was induced in male Wistar rats with streptozotocin injection. The effects of diabetes on latissimus dorsi (LD) muscle contractile and biochemical properties and acute cardiomyoplasty (CDM) were assessed and compared with data from 16 control rats. Isometric force, contractile properties, and fatigue were measured in electrically stimulated muscles (0.3 ms, 1–256 Hz), and Na + K + and Ca 2+ ATPase activities were quantified in muscle membrane preparations. Systolic arterial pressure and aortic blood flow were recorded at rest and during LD muscle stimulation. Compared with control muscle, diabetic muscle showed smaller maximum specific tetanic tension and lower rates of rise and fall in force. Diabetic LD muscle also showed lower muscle enzyme activities. Twitch tension and fatigue did not differ between groups. Smaller increases in aortic flow and systolic pressure after CDM were found in diabetic rats compared to controls. The marked decrease in CDM effectiveness in diabetic rats likely reflected the alterations in muscle properties associated with diabetes.