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Arresting Dialysis‐Related Amyloidosis: A Prospective Multicenter Controlled Trial of Direct Hemoperfusion with a β 2 ‐Microglobulin Adsorption Column
Author(s) -
Gejyo Fumitake,
Kawaguchi Yoshindo,
Hara Shigeko,
Nakazawa Ryoichi,
Azuma Nakanobu,
Ogawa Hiroshi,
Koda Yutaka,
Suzuki Masashi,
Kaneda Hiroshi,
Kishimoto Hidefumi,
Oda Mizue,
Ei Kyoko,
Miyazaki Ryoichi,
Maruyama Hiroki,
Arakawa Masaaki,
Hara Mitsuru
Publication year - 2004
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2004.47260.x
Subject(s) - hemoperfusion , amyloidosis , beta 2 microglobulin , dialysis , medicine , adsorption , dialysis tubing , prospective cohort study , surgery , gastroenterology , hemodialysis , chemistry , membrane , biochemistry , organic chemistry
We investigated the clinical efficacy of direct hemoperfusion with a β 2 ‐microglobulin (β 2 ‐m) adsorption column for the treatment of patients with dialysis‐related amyloidosis. A 2‐year prospective controlled study was performed to compare the effects of passaging blood through a (β 2 ‐m) adsorption column (Lixelle) before it is passaged through the dialysis polysulfone membrane on the severity of amyloidosis in these individuals. Patients ( n = 22) whose blood went through the Lixelle column prior to dialysis had a higher β 2 ‐m removal rate compared to an equal number of controls, and they showed earlier improvement in their symptoms which included impaired daily activities, joint stiffness, and pain. The appearance of additional bone cysts was prevented in pre‐adsorbed patients but not in the controls. Thus, the Lixelle column is useful in preventing the progression of dialysis‐related amyloidosis and in ameliorating or arresting the progression of the symptoms of this disorder.