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Physiologic‐insensitive Left Ventricular Assist Predisposes Right‐sided Circulatory Failure: A Pilot Simulation and Validation Study
Author(s) -
Reesink Koen,
Dekker André,
Van Der Nagel Theo,
Blom Hans,
Soemers Cecile,
Geskes Gijs,
Maessen Jos,
Van Der Veen Erik
Publication year - 2004
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2004.07380.x
Subject(s) - circulatory system , ventricular assist device , medicine , cardiology , circulatory failure , perfusion , heart failure
Right‐sided circulatory failure (RSCF) is a serious complication in 15–30% of patients receiving a left ventricular assist device (LVAD). It is hypothesized that left ventricular support which lacks physiologic properties predisposes to RSCF. An integral computer simulation and experimental validation protocol was performed. The results suggest that with conventional insensitive left ventricular support right‐sided circulatory function is compromised, which may form a substrate for the onset or progress of RSCF. Feedback control of the LVAD could provide a means to counter this problem. A control concept for the LVAD which aims to preserve right‐sided circulatory function, while supporting peripheral perfusion, is proposed