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Application of a Pressure‐relieving Air Compliance Chamber in a Single‐pulsatile Extracorporeal Life Support System: An Experimental Study
Author(s) -
Kim Tae Sik,
Sun Kyung,
Lee Kyu Baek,
Lee Hye Won,
Baek Kwang Je,
Park Sung Young,
Son Ho Sung,
Kim Kwang Taik,
Kim Hyoung Mook
Publication year - 2004
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2004.07341.x
Subject(s) - pulsatile flow , extracorporeal , compliance (psychology) , oxygenator , hemodynamics , membrane oxygenator , medicine , blood flow , extracorporeal circulation , cardiopulmonary bypass , anesthesia , peristaltic pump , biomedical engineering , surgery , mechanical engineering , psychology , social psychology , engineering
Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure‐relieving compliance chamber in a circuit might reduce blood cell trauma was tested. An extracorporeal life support circuit was constructed in an acute lung injury model of dogs by oleic acid infusion. The animals were divided into three groups. In group I ( n = 6) a nonpulsatile centrifugal pump was used as a control. In group II ( n = 4) a single‐pulsatile pump was used, and in group III ( n = 6) a single‐pulsatile pump equipped with a compliance chamber was used. Pump flow was maintained at 1.8–2.0 L/min for 2 h. Hemodynamics and blood gas analyses indicated that the pulsatile groups II and III had better results than the nonpulsatile group I. The plasma‐free hemoglobin level, which indicates blood cell trauma, was the lowest in group I and the highest in group II but was significantly decreased in group III. A pressure‐relieving compliance chamber could significantly reduce high circuit pressures and blood cell trauma.