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Treatment of Full‐thickness Skin Defect with Concomitant Grafting of 6‐fold Extended Mesh Auto‐skin and Allogeneic Cultured Dermal Substitute
Author(s) -
Kashiwa Naohiro,
Ito Osamu,
Ueda Takeshige,
Kubo Kentaro,
Matsui Hiromichi,
Kuroyanagi Yoshimitsu
Publication year - 2004
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2004.00009.x
Subject(s) - skin grafting , medicine , hyaluronic acid , artificial skin , surgery , concomitant , grafting , dermatology , chemistry , anatomy , organic chemistry , polymer
The aim of this clinical study was to evaluate an allogeneic cultured dermal substitute (CDS) as a biological dressing for highly extended mesh auto‐skin grafting. The subjects were five patients with extensive deep burn wounds. Allogeneic CDS was prepared by seeding fibroblasts on a spongy matrix of hyaluronic acid and atelo‐collagen. Six‐fold extended auto‐skin graft was applied to the debrided wound, on which allogeneic CDS was placed. A conventional ointment‐gauze dressing was used to protect the CDS. The CDS was applied repeatedly at intervals of 5–7 days. In all cases, the wounds were closed by successful take of mesh auto‐skin graft and prompt epithelization from the grafted skin. The skin on the grafted area had a cicatrix appearance, but was soft and thin, maintaining good quality. The application of 6‐fold extended auto‐skin graft in conjunction with allogeneic CDS is an effective method for treatment of extensive severe burn wounds.