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Effect of Hemodiafiltration on Pulmonary Hemodynamics in Endotoxic Shock
Author(s) -
Lambermont B.,
Kolh P.,
Ghuysen A.,
Moonen M.,
Morimont P.,
Gérard P.,
TchanaSato V.,
Rorive G.,
D’Orio V.
Publication year - 2003
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2003.07221.x
Subject(s) - hemodynamics , septic shock , medicine , shock (circulatory) , vascular resistance , haemodynamic response , anesthesia , pulmonary hypertension , cardiac output , sepsis , cardiology , heart rate , blood pressure
Hemofiltration can improve pulmonary hemodynamics during septic shock. The main objective of the study was to determine whether hemodiafiltration (HDF) would also have beneficial effects on pulmonary hemodynamics during septic shock. In the Endo group, six anesthetized pigs received a 0.5 mg/kg endotoxin infusion over 30 min. In the HDF group ( n = 6), HDF was started 30 min after the end of the endotoxin infusion, while in the Control group ( n = 4) they received HDF but no endotoxin infusion. Pulmonary hemodynamics were analyzed in detail with a four‐element windkessel model. Although in the Control group, HDF did not alter pulmonary hemodynamic parameters, in the HDF group, it was responsible for an amplification of the deleterious pulmonary vascular response to endotoxin insult. Our results show that HDF must be used cautiously in septic shock since it can precipitate right heart failure by increasing pulmonary vascular resistance.