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An Evaluation of a Polyethersulfone Hollow Fiber Plasma Separator by Animal Experiment
Author(s) -
Changsheng Zhao,
Ting Liu,
Zhongping Lu,
Liping Cheng,
Jia Huang
Publication year - 2001
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2001.6655-2.x
Subject(s) - fibrinogen , separator (oil production) , plasma , hemolysis , chromatography , chemistry , albumin , blood proteins , membrane , platelet , blood plasma , materials science , immunology , medicine , biochemistry , physics , quantum mechanics , thermodynamics
Membrane plasma separators are being used routinely for therapy in various diseases. In this study, a newly developed plasma separator made of polyethersulfone (PES) hollow fibers was evaluated for its plasma filtration efficiency and blood compatibility by animal experiment. Hemolysis did not occur under the usual conditions of plasma separation. The sieving coefficients of total protein and albumin were over 95%, and the total cholesterol was over 90% throughout the perfusions. Decreases in white blood cells, platelets, fibrinogen, and coagulation factors were observed during the early stage of plasma separation, but appear to be within acceptable ranges for clinical use.