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Renal Circulation and Cellular Metabolism During Left Ventricular Assisted Circulation: Comparison Study of Pulsatile and Nonpulsatile Assists
Author(s) -
Sezai Akira,
Shiono Motomi,
Orime Yukihiko,
Nakata Kinichi,
Hata Mitsumasa,
Yamada Hideaki,
Iida Mitsuru,
Kashiwazaki Satoshi,
Kinishita Junichi,
Nemoto Mitsuhiro,
Koujima Takashi,
Sezai Yukiyasu,
Saitoh Toshimi
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb03752.x
Subject(s) - pulsatile flow , circulation (fluid dynamics) , systemic circulation , cardiology , renal circulation , medicine , coronary circulation , hemodynamics , blood flow , renal blood flow , mechanics , physics
We examined left ventricular assist during 6 h for an acute myocardial infarction model in pigs. The outflow cannula was placed in the ascending aorta and an inflow cannula in the left atrium. A pump (Pulsatile group: Zeon Medical and Nonpulsatile group: Nikkiso HPM‐15) was connected to each cannula. Items measured were the regional blood flow of the cortex and the medulla in the kidney, renal arterial flow, arterial blood ketone body ratio (AKBR), lactate/pyruvic acid, BUN, creatinine and β 2 ‐microglobulin. After experimental study, the kidneys were removed, and a pathological study was performed. In the pulsatile assisted group, renal cortical blood flow increased but medulla blood flow decreased. On the other hand, in the nonpulsatile assisted group, both regional blood flows decreased. That means that in the pulsatile assisted group intrarenal redistribution improved, rather than in the nonpulsatile assisted group. The results of our study indicated that pulsatile assist produced superior circulation in the kidney, and the microcirculation on the cell level was superior as well in early treatment of acute left heart failure.