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Prevention of Remote Organ Injury in Cardiopulmonary Bypass: The Impact of Flow Generation Technique
Author(s) -
Hyde Jonathan A.J.,
Riddington David W.,
Hutton Peter,
Wilson Ian C.,
Boivin Christopher M.,
Nash Gerard,
Graham Timothy R.
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb03751.x
Subject(s) - cardiopulmonary bypass , pulsatile flow , medicine , permeability (electromagnetism) , intestinal permeability , cardiology , revascularization , chemistry , biochemistry , membrane , myocardial infarction
The purpose of this study was to investigate the effects of 3 different types of flow generation for cardiopulmonary bypass on gastrointestinal permeability and on neutrophil expression of CD11b, a surface marker of neutrophil activation. Fourteen patients undergoing elective coronary revascularization were selected randomly to receive 1 of the 3 flow generation techniques (roller, pulsatile, or centrifugal). Intestinal permeability was assessed by the fraction of an oral dose of 51 chromium‐ethylenedi‐aminetetraacetate ( 51 Cr‐EDTA) recovered in the urine over 24 h. Neutrophil activation was determined by expression of CD11b markers at 6 time points. Overall, the 14 patients showed significant increases in intestinal permeability. It was not possible to demonstrate statistically significant differences among the flow generation groups: however, when compared to both roller pump groups, the centrifugal pump group showed a 3.2% reduction in intestinal permeability. There was no change in the expression of CD11b receptors throughout the time points, nor was there a relationship of CD11b markers to the flow generation technique.