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A Newly Developed Silicone‐Coated Membrane Oxygenator for Long‐Term Cardiopulmonary Bypass and Cardiac Support
Author(s) -
Iida Mitsuru,
Shiono Motomi,
Orime Yukihiko,
Nakata Kinichi,
Hata Mitsumasa,
Sezai Akira,
Yamada Hideaki,
Kashiwazaki Satoshi,
Nemoto Mitsuhiro,
Kinoshita Junichi,
Sezai Yukiyasu
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb03736.x
Subject(s) - cardiopulmonary bypass , oxygenator , membrane oxygenator , silicone , medicine , anesthesia , surgery , materials science , composite material
The surface of polypropylene hollow fiber was successfully coated with a very thin (0.2 μm) silicone layer. Experimental studies were performed in long‐term (6 h) normothermic cardiopulmonary bypass (CPB) using 10 goats. A conventional membrane oxygenator (Mera Exce‐lung HPO‐lSH, MERA, Tokyo, Japan) was used for 5 goats as a control (Group C) and a new silicone‐coated membrane oxygenator, which is of the same construction as that of the one used for Group C, for 5 (Group S). The O 2 transfer and CO 2 removal functions showed the same ranges. In the other parameters, there were no differences between the 2 groups. As for hemolysis, however, the plasma free hemoglobin of Group S was lower than that of Group C. Currently, 3 chronic percutaneous cardiopulmonary support (PCPS) experimental models have been conducted, and there has been no evidence of thromboembo‐lism or deterioration of the oxygenator. In conclusion, this new oxygenator is suitable not only for CPB, but also for long‐term cardiac support.