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Long‐Term Evaluation of a Nonpulsatile Mechanical Circulatory Support System
Author(s) -
Wakisaka Yoshinari,
Taenaka Yoshiyuki,
Chikanari Kenichi,
Nakatani Takeshi,
Tatsumi Eisuke,
Masuzawa Tom,
Nishimura Takashi,
Takewa Yoshiaki,
Ohno Takashi,
Takano Hisateru
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb03714.x
Subject(s) - circulatory system , thrombus , creatinine , blood flow , transaminase , materials science , biomedical engineering , medicine , chemistry , cardiology , biochemistry , enzyme
Antithrombogenicity of a centrifugal pump (CP) developed in our institute is provided by a central balancing hole (BH) in the impeller. A current CP, the National Cardiovascular Center (NCVC)‐2, was ameliorated to improve antithrombogenicity, whereby the BH diameter was widened to improve self washout flow velocity, and an edge of the thrust bearing was rounded off to minimize flow separation. Effects of these modifications were assessed in a long‐term in vivo experiment. The antithrombogenicity, hemolytic property, and mechanical durability of the NCVC‐2 were investigated in 3 goats. The NCVC‐2 was installed paracorporeally between the left atrium and the aorta and driven as long as possible at rotating speeds of about 2,800 rpm. The NCVC‐2 ran for 50, 200, and 367+ days. The mean bypass flow rates were 6.8, 5.0, and 5.3 Wmin, respectively. Creatinine, blood urea nitrogen (BUN), glutamic‐oxaloacetic transaminase (GOT), and glutamic‐pyruvic transaminase (GPT) did not increase until one week before termination. Plasma free hemoglobin was kept to a level less than 15 mg/dl, except for the last week of the second case. These results indicate that the NCVC‐2 has excellent antithrombogenicity, an acceptable hemolytic property and the necessary durability for prolonged use.