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Effects of Pulsatile Flow on Gas Transfer of Membrane Oxygenator: MENOX EL‐4000 and Gyro C1‐E3 Pulsatile Mode
Author(s) -
Tayama Eiki,
Niimi Yoshinari,
Takami Yoshiyuki,
Ohashi Yukio,
Ohtsuka Goro,
Nakazawa Tadashi
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb00454.x
Subject(s) - pulsatile flow , flow (mathematics) , membrane oxygenator , materials science , mechanics , medicine , anesthesia , cardiology , cardiopulmonary bypass , physics
It is acknowledged that pulsatile flow enhances the gas exchange performance of membrane oxygenators. However, the data for currently developed oxygenators are limited. In this study, the effect of pulsatile flow was assessed utilizing the MENOX EL‐4000 oxygenator. The in vitro test was performed following the Association for the Advancement of Medical Instrumentation (AAMI) standards. Pulsatile flow was produced by the Gyro C1‐E3 centrifugal pump with periodical changing of the impeller speed. In Study 1, the following 3 groups were created and examined: nonpulsatile flow, pulsatile flow of 40 bpm, and pulsatile flow of 60 bpm. The blood flow rate was maintained at 3 LImin, and the VIQ ratio was I. In Study 2, four groups were examined, nonpulsatile flow with V/Q = 1, nonpulsatile with V/Q = 2, pulsatile with VIQ = 1, and pulsatile with V/Q = 2. The blood flow rate was maintained at 4 LImin, and the pulse frequency was set at 40 bpm. In study 1, although 0, transfer was not enhanced. CO 2 , transfer was significantly improved (40–50%) by pulsatile flow, regardless of pulse frequency. Study 2 demonstrated that pulsatile flow resulted in improved CO 2 transfer as did higher ventilation (VIQ = 2). Furthermore, even after applying higher ventilation, the pulsatile mode enhanced CO 2 transfer more than the nonpulsatile mode. It was considered that the pulsatile mode induced an active secondary flow and enhanced mixing effects, and consequently CO 2 transfer was improved. In conclusion, the pulsatile flow significantly enhanced the CO 2 transfer of the MENOX oxygenator. It is indicated that applying the pulsatile mode is a unique and effective method to improve the gas exchange performance for a current membrane oxygenator.