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Effects of Ultrathin Silicone Coating of Porous Membrane on Gas Transfer and Hemolytic Performance
Author(s) -
Niimi Yoshinari,
Ueyama Keishi,
Yamaji Ken,
Yamane Shingo,
Tayama Eiki,
Sueoka Akinori,
Kuwana Katsuyuki,
Tahara Koichiro,
Nosé Yukihiko
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb00446.x
Subject(s) - oxygenator , membrane oxygenator , materials science , glutaraldehyde , membrane , microporous material , volumetric flow rate , silicone , chemical engineering , biomedical engineering , composite material , chemistry , chromatography , extracorporeal membrane oxygenation , anesthesia , medicine , cardiopulmonary bypass , biochemistry , physics , quantum mechanics , engineering
To assess the effect of an ultrathin (0.2 μm) silicone‐coated microporous membrane oxygenator on gas transfer and hemolytic performance, a silicone‐coated capillary membrane oxygenator (Mera HP Excelung‐prime, HPO‐20H‐C, Senko Medical Instrument Mfg. Co., Ltd. Tokyo, Japan) was compared with a noncoated polypropylene microporous membrane oxygenator of the same model and manufacturer using an in vitro test circuit. The 2 oxygenators showed little difference in the oxygen (O 2 ) transfer rate over a wide range of blood flow rates (1 L/min to 8 L/min). The carbon dioxide (CO 2 ) transfer rate was almost the same in both devices at low blood flow rates. but the silicone‐coated oxygenator showed a decrease of more than 20% in the CO 2 transfer rate at higher blood flow rates. This loss in performance could be partly attenuated by increasing the gas/blood flow ratio from 0.5 or 1.0 to 2.0. In the hemolysis study, the silicone‐coated membrane oxygenator showed a smaller increase in plasma free hemoglobin than the noncoated oxygenator. The pressure drop across both oxygenators was the same. These results suggest that the ultrathin silicone‐coated porous membrane oxygenator may be a useful tool for long‐term extracorporeal lung support while maintaining a sufficient gas transfer rate and causing less blood component damage.