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Do Sheep Really Have Problems with Cardiopulmonary Bypass for Total Artificial Heart Implantation?
Author(s) -
Kim Won Gon,
Kim Young Tae,
Park Sung Keun,
Kim Hee Chan,
Suh Jung Wook,
Park Jong Wan,
Paik Wan Ki,
Lee Bung Han,
Min Byoung Goo,
Rho Joon Ryang
Publication year - 1997
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1997.tb00353.x
Subject(s) - cardiopulmonary bypass , medicine , hemolysis , artificial heart , lung , artificial lung , surgery , pathophysiology , anesthesia , cardiology
Although the use of sheep in total artificial heart (TAH) implantation has many advantages, they are known to show a significant morbidity rate on cardiopul‐monary bypass (CPB); this has been considered to be a major limiting factor in using them for TAH experiments. We conducted a series of ovine CPB experiments to evaluate the sheep's pathophysiological response to CPB. CPB‐related hemolysis, bleeding, and lung dysfunction were analyzed in 5 sheep, which had undergone CPB, used at our hospital for TAH implantation. Four of the 5 sheep survived the experimental procedures, and 3 of them survived on a long‐term basis. Unacceptable degrees of hemolysis related to CPB were not observed. Postoperative bleeding was not remarkable, and coagulation test results did not show significant abnormal findings. Acute lung injuries of a mild to moderate degree were found mainly at the microscopic level, but rarely had clinical significance. In conclusion, this experiment suggests that sheep can be used for the animal model for TAH implantation with acceptable risk on CPB circuits and techniques are used.