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Effects of Perfluorochemical‐Based Artificial Blood Compounds in Discordant Xenotransplantation
Author(s) -
Wada Seishi,
Kajihara Hiroki,
Murakami Hironobu,
Sueda Taijiro,
Matsuura Yuichiro
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb04572.x
Subject(s) - xenotransplantation , guinea pig , blood substitute , pharmacology , heartbeat , medicine , heart transplantation , chemistry , transplantation , hemoglobin , computer security , computer science
Fluosol‐DA and FC43 emulsion were developed as red blood cell substitutes. However, these perfluorochemical (PFC)‐based compounds are not very promising because of their immunosuppressive effects. Therefore we used these compounds as immunosuppressive agents in guinea pig‐to‐rat discordant heart xenotransplantations. In rats treated with these compounds (5 μl/g body weight), rhythmic beating of the hearts was maintained for 265.7 ± 50.3 min (Fluosol‐DA‐treated group) and 424.3 ± 40.1 min (FC43 emulsion‐treated group), respectively whereas the untreated heartbeat lasted for only 15.5 ± 6.6 min. In the xenografted heart treated with PFC compounds, no pathologic changes, such as multiple coronary thromboses due to hyperacute rejection, had occurred by 3–4 h after reperfusion, and the endothelial cells were well preserved. We conclude that these PFC compounds can prolong the survival time of guinea pig heart xenografts by inhibiting thrombus formation in the xenografted heart.