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Interaction Between Cell‐Surface‐Expressed 70‐Kilodalton Heat Shock Protein‐like Antigen and CD3 + 4 ‐ 8 ‐ Killer T Cells
Author(s) -
Takashima Satoru,
Sato Noriyuki,
Kishi Akihiko,
Tamura Yasuaki,
Sagae Satoru,
Kudo Ryuichi,
Torigoe Toshihiko,
Yagihashi Atsuhito,
Kikuchi Kokichi
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb04559.x
Subject(s) - kilodalton , heat shock protein , microbiology and biotechnology , cell , antigen , hsp70 , cd3 , shock (circulatory) , receptor , mutant , chemistry , biology , biochemistry , immunology , gene , cd8 , medicine
The 70‐kilodalton heat shock proteins may be expressed on the cell surface by an unknown mechanism and may interact with CD3 + 4 ‐ 8 ‐ T cell receptor‐αβ ‐ killer (DNT) cells. In this interaction, certain cellular nascent or mutant peptides may be important (the complexes of 70‐kilodalton heat shock protein and cellular peptides directly interact with DNT cells). The results imply that the interaction between 70 kilodalton heat shock proteins and DNT cells may also work in graft rejection. By using antibodies that react with the cell surface‐expressed 70‐kilodalton heat shock proteins, one may overcome graft rejection. Key Words: Heat shock proteins–T cells–Cellular peptides–Molecular chaper‐ones.