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BCX‐34: A Novel T‐Cell Selective Immunosuppressant: Purine Nucleoside Phosphorylase (PNP) Inhibitor
Author(s) -
Wada Yoshimasa,
Yagihashi Atsuhito,
Terasawa Katsuhiko,
Miyao Noriomi,
Hirata Koichi,
Cicciarelli James,
Iwaki Yuichi
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb04557.x
Subject(s) - purine nucleoside phosphorylase , chemistry , in vitro , pharmacology , purine , nucleoside , purine analogue , drug , biochemistry , enzyme , biology
We evaluated the efficacy of a new purine nucleoside phosphorylase inhibitor, BCX‐34, as an immunosuppressive agent. BCX‐34 showed a complete inhibitory effect on the proliferation of T‐cells in an in vitro system, whereas no influence was observed in B‐cell lines. In addition, it was revealed that this inhibitory effect was not due to the suppression of interleukin‐2 production. Therefore, BCX‐34 might be a potentially useful drug that can be used in combination, not competition, with cyclosporine A and FK506.