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The Significance of Adhesion Molecules in Nephrology
Author(s) -
Burkhardt Klaus,
Hillebrand Günther,
Bösnecker Angela,
Land Walter,
Gurland HansJürgen
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb04528.x
Subject(s) - cell adhesion molecule , nephrology , cell adhesion , function (biology) , adhesion , soluble cell adhesion molecules , medicine , immune system , cancer research , microbiology and biotechnology , immunology , biology , chemistry , organic chemistry
Our knowledge of adhesion molecules has exploded over the last 5 years and has swamped most fields of medicine including nephrology. This is not surprising because adhesion molecules play a pivotal role in all aspects of cell to cell contact. Thus, they are involved in important issues, such as fetal development, in any kind of inflammatory or immune response including allograft rejection, as well as thrombus formation, and in tumor growth and metastasis (1–3). This short overview briefly reports some aspects of the biology of relevant adhesion molecules and their significance in inflammatory kidney diseases and in hemodialysis and renal allograft rejection. Finally, new therapeutic opportunities that arise by blocking adhesion molecule function are discussed.