Premium
In Vitro and In Vivo Testing of an Implantable Motor‐Driven Left Ventricular Assist Device
Author(s) -
Murakami Taiji,
Kikugawa Daiki,
Fukuhiro Yoshiaki,
Kanazawa Shigeo,
Fujiwara Takashi,
Katsumura Tatsuki,
Kukunaga Shintaro,
Matsuura Yuichiro
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb00719.x
Subject(s) - afterload , ventricular assist device , cannula , artificial heart , cardiology , peristaltic pump , biomedical engineering , materials science , left atrial pressure , circulatory system , hemodynamics , medicine , heart failure , surgery , mechanical engineering , engineering
A totally implantable motor‐driven left ventricular assist device (LVAD) has been developed and tested. The performance of this LVAD was tested in a mock circulatory system. This pump provided 8 L/min of output against a mean afterload of 120 mm Hg with a filling pressure of 20 mm Hg when the pump was operated in the fill/empty mode. The right and left pumps were tested in a mock loop. The right pump afterload was kept in the range from 23–32 mm Hg. With increase in the left pump afterload, the pump power output varied from 1.64 to 2.37 W. The instantaneous motor power input varied from 22.6 to 30.6 W with the total system efficiency ranging from 6.7 to 9.4%. To date, 4 in vivo studies have been conducted for up to 12 h. Two animals survived 12 and 10 h, respectively. Termination was due to bleeding in 1 animal, vent tube obstruction in 1, and respiratory failure in 2. All animals died of technical failure. Another experiment is to be undertaken, and a newly designed cannula is now being manufactured.