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Development of a Potassium‐Specific Adsorbent for Direct Hemoperfusion
Author(s) -
Terai Chikanori,
Shimizu Shoichiro,
Matsushima Shunsuke,
Tanaka Ikuo,
Okada Yoshiaki,
Miyahara Tadashi,
Nakaji Shuhei
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb00665.x
Subject(s) - hemoperfusion , chemistry , potassium , magnesium , sodium , calcium , electrolyte , lithium (medication) , chromatography , nuclear chemistry , medicine , organic chemistry , hemodialysis , electrode
Direct hemoperfusion (DHP) over an exchange resin for sodium is capable of rapidVVly lowering an vated serum potassium level but has not been used clin‐ ically because of subsequent electrolyte abnormalities. After the completion of detailed in vitro studies, we de‐ veloped a sodium/calcium/magnesium exchange resin mixture specifically to remove potassium from the blood. The mixture, which consisted of exchange resins for so‐ dium (48%), calcium (48%), and magnesium (4%), gave the most satisfactory results in vitro. DHP through these resin‐mixture columns for 2 h reduced elevated plasma potassium levels (6.7 ± 1.1 to 3.5 ± 0.6 mEq/L, p < 0.001) in anephric dogs without including any significant change in the levels of sodium, calcium, magnesium, al‐ bumin, total protein, or cholesterol. The platelet losses and changes in the plasma free hemoglobin levels ob‐ served were similar to those found with activated char‐ coal hemoperfusion. These results suggest that this resin hemoperfusion may be useful in patients with acute hyperkalemia.