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Study of the Changes of Serum Hyaluronic Acid During Porcine Liver Transplantation: Influence of Warm Ischemia
Author(s) -
Nakajima Yasuaki,
Kimura Jun,
Isai Hideya,
Tamura Motoshi,
Ito Koji,
Kon Hirofumi,
Kamachi Hirofumi,
Koike Masahiro,
Kusumoto Kenju,
Uchino Junichi
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb00649.x
Subject(s) - medicine , hyaluronic acid , ischemia , transaminase , revascularization , liver transplantation , intracardiac injection , transplantation , surgery , anatomy , chemistry , biochemistry , myocardial infarction , enzyme
Twelve porcine liver transplantations were performed to investigate whether serum hyaluronic acid (HA) serves as a marker of warm ischemic injury. Group 1 was a control without warm ischemia (n = 7), and pigs in Group 2 were sacrificed by intracardiac KC1 injection 60 min before harvesting (n = 5). All pigs survived more than 4 days in Group 1. In Group 2, all died within 2 days due to graft failure. Arterial and hepatic venous glutamic‐oxaloacetic transaminase (GOT) in Group 2 were higher after revascularization. However, there were no differences between the 2 groups in arterial and hepatic venous HA levels. HA clearance by the graft also showed no differences between the groups. Although GOT reflected the degree of warm ischemia, HA and its hepatic clearance were not influenced by warm ischemic damage. In conclusion, HA was not thought to serve as a marker of liver injury when the graft suffered from warm ischemia.