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Prolongation of Rat Liver Graft Survival by Splenectomy Combined with Low Dose FK506 Therapy
Author(s) -
Kashu Yasuaki,
Abe Yasuhito,
Miyauchi Katsutoshi,
Watanabe Yuji,
Sato Motomichi,
Sato Naoshi,
Kimura Shigeru
Publication year - 1996
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1996.tb00647.x
Subject(s) - splenectomy , medicine , surgery , urology , gastroenterology , spleen
The effects of low dose FK506 therapy (0.1 mg/kg/day × 1 day) on graft survivals were analyzed, and the feasibility of splenectomy was assessed. ACI strain liver grafts were orthotopically implanted into LEW male rat recipients. In the control group, the survival period was 10.4 ± 1.4 days. In the group treated with splenectomy, the survival period was 13.4 ± 2.0 days. In the groups with low dose FK506 therapy, the survival periods were 22.7 ± 6.7 and 39.7 ± 6.3 days with or without splenectomy, respectively. Rats in the group with average dose FK.506 (1.0 mg/kg/day × 7 days) survived more than 100 days. In summary, the effect of low dose FK506 therapy was relatively limited. Splenectomy by itself was marginally effective; however, this effect was enhanced when combined with low dose FK.506 therapy.