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A Potential Soft Tissue Filling Material: Chloramphenicol Loaded Poly(D, L–Lactide) Sponges
Author(s) -
Kozluca Ahmet,
Denkbaş Emir B.,
Pişkin Erhan
Publication year - 1995
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1995.tb02449.x
Subject(s) - chloramphenicol , acetone , solvent , chemistry , acetonitrile , degradation (telecommunications) , polymer , catalysis , polymer chemistry , nuclear chemistry , polymerization , chromatography , organic chemistry , biochemistry , telecommunications , computer science , antibiotics
Poly(D, L–lactide) (PDLLA) homopolymers were produced by the ring opening polymerization of a D, L–lactide dimer by using stannous chloride as the catalyst. Chloramphenicol loaded PDLLA sponges were prepared by a solvent evaporation procedure by using the PDLLA homopolymers with three different molecular weights (i. e., 11, 000, 20, 000 and 35, 000 daltons). Chloramphenicol loading was changed by using three different solvents (i. e., acetone, ethyl acetate, and acetonitrile) and by changing the initial polymer concentration and its molecular weight and the initial concentration of the drug. Higher degradation rates of the chloramphenicol loaded PDLLA sponges in alkaline pH 9. 0 and at 37°C were observed. Chloramphenicol release rates were also high at these conditions. It was concluded that chloramphenicol release was both degradation and diffusion controlled.