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Function and Metabolism of Brain Synaptosomes in Chronic Renal Failure
Author(s) -
Smogorzewski Miroslaw,
Ni Zhenmin,
Massry Shaul G.
Publication year - 1995
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1995.tb02430.x
Subject(s) - chronic renal failure , renal function , metabolism , brain function , chemistry , medicine , cardiology , neuroscience , biology
Patients with advanced renal failure have derangements in the function of their nervous system. The available clinical and experimental data indicate that the state of the secondary hyperparathyroidism of renal failure plays a major role in the genesis of the nervous system dysfunction. The excess parathyroid hormone (PTH) mediates its deleterious effect by causing an elevation in cytosolic calcium of brain cells. This report reviews the evidence leading to the conclusion that PTH is a major uremic toxin.