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Prevention of Restenosis after Coronary Angioplasty with Low‐Density Lipoprotein Apheresis
Author(s) -
Adachi Hiromasa,
Niwa Akihiro,
Shinoda Toshio
Publication year - 1995
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1995.tb02293.x
Subject(s) - medicine , restenosis , cardiology , ldl apheresis , angioplasty , coronary artery disease , percutaneous transluminal coronary angioplasty , apheresis , artery , stent , platelet
A prospective study was performed to determine whether low‐density lipoprotein (LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty‐six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL‐apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL‐apheresis. Follow‐up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL‐apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia.