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Influence of the Dialyzer Membrane Material on Sodium Transport in Hemodialysis
Author(s) -
Lopot Frantisek,
Kotyk Pavel,
Bláha Jan,
Válek Albert
Publication year - 1995
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1995.tb02278.x
Subject(s) - sodium , hemodialysis , membrane , chemistry , medicine , biochemistry , organic chemistry
Traditionally Gibbs‐Donnan coefficients based on the mean charge of plasma proteins are used as the only correction factor in equations describing sodium transport across the dialyzer membrane. This ignores the possible impact of the membrane material. Correction coefficients (CC) of the whole dialyzer were measured during in vivo dialysis as a quotient of dialysate to plasma sodium in an equilibrated state for different membrane materials used in commercially available dialyzers. Their mean value and correlation with total plasma protein content (TPP) were evaluated. CC for the six materials evaluated differed both in the intercept and slope of the re‐gression line CC versus TPP: Cuprophan 1: CC = 1.0253 − 0.00017 × TPP; Hemophan 1: CC = 1.119 − 0.00175 × TPP; Hemophan 2: CC = 1.095 − 0.00111 × TPP; PMMA: CC = 1.0353 − 0.00044 × TPP; SCE: CC = 1.114 − 0.00145 × TPP; and Cuprophan 1: CC = 1.0562 − 0.00065 × TPP. The observed differences are attributed to the different charge densities of the membrane materials and suggest that for a precise description of sodium transport, the role of the membrane material needs to be considered.