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Improvement of Hemocompatibility on a Cellulose Dialysis Membrane with a Novel Biomedical Polymer Having a Phospholipid Polar Group
Author(s) -
Ishihara Kazuhiko,
Fukumoto Kikuko,
Miyazaki Hideki,
Nakabayashi Nobuo
Publication year - 1994
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1994.tb03379.x
Subject(s) - polymer , cellulose , coating , materials science , copolymer , grafting , chemical engineering , surface modification , polymer chemistry , cellulose fiber , membrane , chemistry , composite material , biochemistry , engineering
To improve surface hemocompatibility on cellulose hollow fibers for hemodialysis, newly designed hemocompatible polymers with a phospholipid polar group, 2–methacryloyloxyethyl phosphory[choline (MPC) polymers, were introduced on the surface through two different methods: direct grafting of MPC on the surface, or coating of a water–soluble cellulose grafted with MPC. The MPC was polymerized using cerium ion as an initiator in the cellulose hollow fibers, and the poly(MPC) chains were grafted directly on the surface. Another modification of the cellulose hollow fibers was attempted by coating them with a water–soluble graft copolymer composed of a poly(MPC) side chain and a cellulose backbone. The coating process from an aqueous solution of the graft copolymer was very convenient, and the graft copolymer on the surface was not detached even after water circulated into the hollow fibers. These cellulose hollow fibers modified with MPC polymers displayed excellent hemocompatibility such as prevention of blood cell adhesion and aggregation after contact with blood without an anticoagulant. The permeability of the hollow fibers did not decrease as a result of these modifications. From these results, it is clearly suggested that introduction of the MPC units was effective for improving the hemocompatibility of the hollow fibers for hemodialysis.