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Clinical Study of High‐Flux Cuprammonium Rayon Hemodialysis Membranes
Author(s) -
Opatrný Karel,
Sylvie Sylvie,
Lopot Frantiŝek,
Vít Ladislav,
Válek Albert,
Opatrný Karel
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb03178.x
Subject(s) - membrane , chemistry , chromatography , ultrafiltration (renal) , dialysis , flux (metallurgy) , biochemistry , surgery , medicine , organic chemistry
The aim of this crossover clinical study was to gain basic information on the hemocompatibility and effectiveness of recently developed high‐flux membranes made of cuprammonium rayon with ultrafiltration coefficients of 10, 17, and 19 ml/mm Hg/h (S12W, SU12W, and SS12W dialyzers, respectively), and to identify any possible differences from a conventional membrane made of the same material with an ultrafiltration coefficient of 6 ml/mm Hg/h (C12W dialyzer). All the tested membranes led to an abrupt drop in leukocyte count in the initial phase of hemodialysis. In high‐flux membranes, C5a anaphylatoxin would pass into the dialysate, but mean C5a anaphylatoxin concentrations in the dialysate were lower by orders of magnitude than its plasma concentrations, which behaved, in high‐ and low‐flux membranes alike, typically of those made of nonsubstituted cellulose with no intermembrane differences. As judged by the concentrations of the thrombin‐antithrombin III complex, the coagulation system was activated—again, without differences between membranes. The reduction rates for urea, creatinine, and phosphates were comparable for all the tested membranes. Compared with baseline, the post‐dialysis serum concentrations of β 2 ‐microglobulin in high‐flux membranes, unlike the low‐flux membrane, were significantly lower. We conclude that there are no significant differences between the tested high‐ and low‐flux membranes made of cuprammonium rayon in the monitored hemocompatibility parameters, and that high‐flux membranes are capable of reducing serum β 2 ‐microglobulin concentrations.