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Urea Kinetic Modeling: Comparing the Options
Author(s) -
Hoenich Nicholas A.,
Keir Michael J.,
Hildreth Kathryn,
Woffindin Celia,
Goodall Robert,
Vanholder Raymond,
Ward Michael K.
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00636.x
Subject(s) - urea , kinetic energy , environmental science , chemistry , biochemistry , physics , quantum mechanics
In this study 6 commercially produced kinetic modeling packages utilizing a variable volume, single pool urea model, as well as formulae to determine the delivery of therapy, have been compared by applying to each the same set of rigorously collected data for a group of 12 patients. Comparison of the kinetically derived parameters (urea generation rate [ G ], urea distribution volume [ V ], delivery of therapy [ Kt/V ], and normalized protein catabolic rate [ nPCR] ) showed that the values obtained for both G and V differed between packages owing to the numerical methods and the clearance used in the solution of the differential equations. Although a broad agreement between the values established for Kt/V and nPCR was noted, the 95% limits of agreement indicated that it would be prudent to exercise caution when comparing results established by different modeling packages.