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Biocompatibility of Leukocyte Removal Filters during Leukocyte Filtration of Cardiopulmonary Bypass Perfusate
Author(s) -
Gu Y.J.,
Obster R.,
Haan J.,
Huet R.C.G. Gallandat,
Eijgelaar A.,
Oeveren W.
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00611.x
Subject(s) - biocompatibility , cardiopulmonary bypass , filtration (mathematics) , cellulose acetate , biomedical engineering , biocompatible material , polyester , chemistry , chromatography , medicine , materials science , cellulose , cardiology , biochemistry , composite material , statistics , mathematics , organic chemistry
To evaluate the biocompatibility and the efficacy of leukocyte removal filters, we performed a prospective study by using the cardiopulmonary bypass perfusate taken from the heart‐lung machine for 20 patients who underwent cardiac surgery and were randomly divided into four groups according to the filters used. A leukocyte removal filter was installed in the transfusion line while the perfusate was transfused to the patients. No increases of C3a, C5a, elastase, and thromboxane were found during leukocyte filtration by polyester filters (Optima, Sepacell R500, and Pall RC100). Activation of the complement cascade was observed during filtration by the cellulose acetate filter (Cellselect) although the efficacy of the Cellselect filter was evidently higher than that of the poly‐ester filter. These results imply that polyester leukocyte filters are superior to cellulose acetate filters in terms of biocompatibility but have a reduced efficacy. An optimal leukocyte filter providing both high efficacy and biocompatibility has yet to be developed.