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Clinical Evaluation of a New Dialyzer, FLX‐12 GW, with a Polyester‐Polymer Alloy Membrane
Author(s) -
Stein G.,
Günther K.,
Sperschneider H.,
Carlsohn H.,
Huller M.,
Schubert K.,
Schaller R.
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00590.x
Subject(s) - membrane , hemodialysis , chromatography , dialysis , chemistry , polyester , polymer , adsorption , alloy , beta 2 microglobulin , dialysis tubing , urology , materials science , surgery , medicine , organic chemistry , biochemistry
The performance of a membrane in renal failure therapy is determined by its structure, its overall mass transfer properties, and its blood compatibility. In this regard. removal of β 2 ‐microglobulin (β2M) has become a major objective of dialysis therapy. In the present study, a newly developed high‐flux membrane composed of a polyester‐polymer alloy (PEPA) with the components of polyarylate and polyethersulfone (dialyzer FLX‐12 GW; Nikkiso Co., Japan) has been evaluated with regard to both hiocompatibility and elimination capacity for β2M during hemodialysis of 8 stable chronic uremic patients. The clearance values of low molecular weight solutes were in the same range as those reported for high‐flux dialyzers of comparable surface area. There was no drop in leukocyte counts and only a minimal fall in platelet counts nearly in the same range as has been observed by other investigators using polyamide membrane. C3a Des Arg generation was low, and C5a Des Arg formation was not significantly influenced. There was a sharp drop in the serum β2M level (‐35%) during dialysis with a clearance between 59.7 ± 5.6 ml/min ( Q B 200 ml/min) and 70.1 ± 9.7 ml/min ( Q B 300 ml/min), respectively. Accordingly, the sieving coefficient was calculated to be 0.2 at 30 min after start of dialysis and 0.6 1 h later. The membrane was able to remove 184.0 ± 22.3 mg/4 h due to an apparent rate of adsorption during the first hour of treatment in combination with high transmembrane transfer in the following time.