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A New Therapeutic Approach to Dialysis Amyloidosis: Intensive Removal of β 2 ‐Microglobulin with Adsorbent Column
Author(s) -
Gejyo Fumitake,
Homma Noriyuki,
Hasegawa Shin,
Arakawa Masaaki
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00574.x
Subject(s) - hemoperfusion , beta 2 microglobulin , amyloidosis , adsorption , dialysis , hemodialysis , chemistry , chromatography , amyloid (mycology) , beta (programming language) , dialysis tubing , surgery , medicine , membrane , biochemistry , organic chemistry , inorganic chemistry , computer science , programming language
Amyloidosis, in which amyloid protein consists of β 2 ‐microglobulin (β 2 ‐M), is both a common and a serious complication of long‐term hemodialysis. The mechanism of its development is not completely understood. Since (β 2 ‐M is an amyloid protein, it is essential to try to remove as much of it as possible. A specific adsorbent of β 2 ‐M has been developed for use in direct hemoperfusion. The adsorbent is a porous cellulose bead to which hydrophobic organic compound is bound covalently. A combination of a high‐flux membrane dialyzer and an adsorption column (BM‐01) would make it possible to efficiently eliminate β 2 ‐M. Dialysis with a combination of direct hemoperfusion (DHP) and an adsorption column led to the elimination of more than 200–300 mg of β 2 ‐M. We observed 5 patients who received treatment with this column (BM‐01) in combination with high‐flux dialysis 3 times a week for periods of 1 week (3 patients), 6 months (I patient), or 14 months (1 patient). It is demonstrated that the adsorbent column (BM‐01) provides an intensive method to eliminate β 2 ‐M from the blood with no serious adverse effect. It thus has the potential to suppress the progression of dialysis amyloidosis. The use of this adsorbent column (BM‐01) in combination with a high‐flux dialyzer may present an improved approach to removing β 2 ‐M from the body.