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Clinical Trials for Removal of Bilirubin by High‐Capacity Nonionic Adsorbent
Author(s) -
Chen Changzhi,
Yu YaoTing,
Song Jichang,
Yuan Ping,
Li Tao,
Du Zhi
Publication year - 1993
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1993.tb00416.x
Subject(s) - bilirubin , hemoperfusion , albumin , adsorption , chemistry , hemoglobin , globulin , urea , electrolyte , benzene , chromatography , transaminase , nuclear chemistry , medicine , biochemistry , organic chemistry , enzyme , hemodialysis , electrode
To remove bilirubin from patients with hyperbilirubinemia, nonionic macroporous adsorbent NK‐110 was tailor‐made from styrene and divinyl benzene at Nankai University. Five patients were perfused through shunts filled with 500 ml of the above adsorbent. After 2 h of hemoperfusion, total bilirubin decreased within the range of 22–51%. During the treatment, no noticeable changes in electrolytes, urea nitrogen, serum glutamicpyruvic transaminase (SGPT), TTT, and amino acid concentrations were observed. Platelet depletion was satisfactory. Hemoglobin, white cell count, globulin, and albumin showed no remarkable changes. The nonionic adsorbent shows a high efficacy for bilirubin removal and has a great potential for future clinical applications.